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News Archive – March 2019

Events for the below selected month

Dynamic host immune response in virus-associated cancers

Posted 29 Mar 2019

Abstract Viruses drive carcinogenesis in human cancers through diverse mechanisms that have not been fully elucidated but include promoting immune escape. Here we investigated associations between virus-positivity and immune pathway alteration... Read more

Non-murine models to investigate tumor-immune interactions in head and neck cancer

Posted 29 Mar 2019

On-line article

The immune response has important roles in the biology of solid tumors, including oncogenesis, tumor growth, invasion and metastasis, and response to treatment. Improved understanding of tumor-immune system interactions has provided promising... Read more

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach

Posted 29 Mar 2019

From the British Journal of Cancer

Background TNM8 staging for oropharyngeal squamous cell carcinomas (OPSCC) surrogates p16 immunohistochemistry for HPV testing. Patients with p16+ OPSCC may lack HPV aetiology. Here, we evaluate the suitability of TNM8 staging for guiding... Read more

Summary of the European public assessment report (EPAR) for Erbitux

Posted 29 Mar 2019

European Medicines Agency

This is a summary of the European public assessment report (EPAR) for Erbitux. It explains how the Committee for Medicinal Products for Human Use (CHMP) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and... Read more

Review of inbound medical tourism and legal details of obtaining a visa for treatment of head and neck cance

Posted 29 Mar 2019

Case report from the United States

Methods We reviewed current statistics and the medical and legal literature regarding inbound medical tourism and the process of obtaining a visa for patients traveling to the United States for medical treatment. To illustrate this process, we... Read more

Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma

Posted 15 Mar 2019

Scientific Report

Recently, exosomes secreted by menstrual mesenchymal stem cells have been identified as inhibitory agents of tumor angiogenesis and modulators of the tumor cell secretome in prostate and breast cancer. However, their direct effect on endothelial... Read more

Bill introduced to make oral cancer medication more affordable

Posted 15 Mar 2019

News from America

WASHINGTON, D.C. — There’s a new effort on Capitol Hill to make newer cancer treatment options more affordable. U.S. Senator Tina Smith (D-Minnesota) along with U.S. Senator Jerry Moran (R-Kansas) re-introduced the “Cancer Drug Parity Act”... Read more

The NKG2A immune checkpoint

Posted 15 Mar 2019

A new direction in cancer immunotherapy

Inhibition of the NKG2A immune checkpoint restores natural killer cell and T cell effector function in preclinical cancer models. In addition, NKG2A blockade in combination with other therapeutic antibodies is showing encouraging responses in a... Read more

Oncoproteomic and gene expression analyses identify prognostic biomarkers for second primary malignancy

Posted 15 Mar 2019

Hopes for earlier diagnosis and better survival outcome in patients with head and neck cancer.

Patients with head and neck squamous cell carcinoma are at increased risk of developing a second primary malignancy, which is associated with poor prognosis and early death. To help improve clinical outcome, we aimed to identify biomarkers for... Read more

Depiction of Oral Tumor-Induced Trigeminal Afferent Responses Using Single-Fiber Electrophysiology

Posted 15 Mar 2019

Considerable gap in knowledge exists about the mechanisms by which oral tumors regulate peripheral sensory fibers to produce pain and altered sensations. To address this gap, we used a murine model of oral squamous cell carcinoma (OSCC) of the... Read more

BAHNO Research Grants

Posted 04 Mar 2019

Two awards given this year

BAHNO is pleased to announce that, due to the high standard of applications, the Research Committee has decided to make two awards this year. The recipients are: Paula Bradley (University of Sunderland) - who will receive £3,000 to develop... Read more